ProstaStream Review: A Fully Dosed Label With 255% of the Daily Value of Selenium: Is $69 a Bottle Worth It? (2026)
ProstaStream is a two-capsule-a-day prostate supplement sold direct through DigiStore24 checkout at $69 for one bottle, $59 per bottle for three, and $49 per bottle for six, with free US shipping on every package and a 60-day money-back guarantee counted from the shipment date. Unlike most products in this category it does not hide behind a single proprietary blend: the Supplement Facts panel gives individual amounts for five vitamins and minerals and thirteen botanicals, with only a 142 mg blend of fourteen minor ingredients left undisclosed. We read the vendor's text presentation, the Supplement Facts label, the refund and shipping policies and the references page, then checked every ingredient claim against PubMed. The disclosure deserves credit. The choices do not always survive the check: saw palmetto is at 200 mg when 320 mg and even 960 mg both failed against placebo in NEJM and JAMA trials, the nettle is leaf rather than the root the sales page names and the trials used, and the label carries 140 mcg of selenium, 255% of the Daily Value, the exact dose range that increased high-grade prostate cancer risk in a SELECT analysis of men who already had good selenium status.
Daniel Rodriguez
Men's Health & Wellness Writer
Last updated: September 6, 2026
Disclosure: This review contains affiliate links. If you purchase through our links, we may earn a commission at no extra cost to you. Read our affiliate disclosure and editorial policy.
Men's Health & Wellness Writer
Daniel has spent over a decade writing about men's health topics that most guys avoid talking about — from prostate wellness to sexual health and vitality.
At a glance
Best for
- Men 45-75 with mild to moderate nighttime frequency or weak stream that a urologist has already worked up
- Buyers who specifically want to see per-ingredient milligram amounts rather than a single proprietary blend
- Men interested in the plant sterol / beta-sitosterol approach, which has the better placebo-controlled record of the two lead ingredients
- People who are not currently taking a multivitamin, a men's formula, or any other product containing selenium
- Buyers who can commit to the 3- or 6-bottle order so the 60-day window from shipment is not the limiting factor
Not for
- Any man who has not had a PSA test and a digital rectal exam; the same symptoms come from prostate cancer, bladder stones, urethral stricture, and diabetes, and no supplement can tell them apart
- Men already taking a multivitamin, a prostate multi, or a Brazil-nut habit; stacking 140 mcg of selenium on top of that is the wrong direction
- Anyone hoping a supplement will replace tamsulosin, finasteride, or dutasteride, which have multi-year randomized outcome data no botanical has
- Vegetarians and vegans: the capsule is bovine gelatin
- Anyone with a soy allergy; the label states 'Contains Soy (Plant Sterols)'
- Men on warfarin, blood-pressure medication, lithium, or diabetes medication without a pharmacist's sign-off; goldenseal, green tea, uva ursi, and cayenne all have interaction potential
ProstaStream price & where to buy
- Price: from $49 per bottle (single bottle $69) · Save up to $300 on 6 bottles
- Guarantee: 60-day money-back guarantee
- Where to buy: only on the official ProstaStream website — not sold in stores, on Amazon or Walmart.
ProstaStream still worth it in 2026?
The most transparent label we have read in this category, attached to a saw-palmetto-first formula whose two best trials were both negative, and a selenium dose we would not take without a blood test
"Nights went from four bathroom trips to two or three around week six. My urologist said keep taking it if it helps and keep coming in for the PSA."
"I liked that the bottle actually tells you 200 mg of saw palmetto and 300 mg of sterols instead of hiding it in a blend. Then I looked up saw palmetto and it did nothing in the big studies."
"Nobody warned me the selenium was two and a half times the daily value. I take a multivitamin too. My doctor told me to stop one of them."
- Individual doses are printed for eighteen of the thirty-two ingredients, including the two that matter most: saw palmetto 200 mg and plant sterol complex 300 mg. Almost nothing else in this category does that.
- The plant sterol complex is the one component plausibly at a trial-level dose. Beta-sitosterol at 60 mg per day improved symptom scores and peak flow in a 200-patient Lancet trial; a 300 mg sterol complex could deliver that, though the label does not say what fraction is beta-sitosterol.
- Saw palmetto, the ingredient the sales page leads with, is at 200 mg. The 225-man NEJM trial used 320 mg a day and found no difference from placebo; the 369-man CAMUS trial went up to 960 mg a day and still found none.
- 140 mcg of selenium is 255% of the Daily Value and above the RDA. A SELECT case-cohort analysis found selenium supplementation raised high-grade prostate cancer risk by 91% in men whose baseline selenium was already in the top 40%, and its authors concluded men should avoid selenium above recommended dietary intakes.
Best suited to men with mild, doctor-evaluated urinary symptoms who want a disclosed-dose botanical formula, who are not taking any other selenium-containing supplement, and who have had a PSA and a digital rectal exam first.
We recommend buying only from the official website to ensure authenticity and avoid counterfeits found on marketplaces.
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What is ProstaStream?
A two-a-day prostate capsule that prints its doses, led by saw palmetto and a 300 mg plant sterol complex
ProstaStream is a 60-capsule, two-a-day prostate supplement distributed by a company of the same name at 37 Inverness Drive East, Suite 100, Englewood, Colorado. Checkout runs through DigiStore24, and refunds are mailed to a separate Aurora, Colorado address. Each two-capsule serving carries Vitamin E 13 mg as d-alpha tocopheryl succinate (87% DV), Vitamin B6 3.33 mg (196%), zinc 10 mg as zinc oxide (91%), selenium 140 mcg as selenium gluconate (255%), and copper 0.2 mg as an amino acid chelate (22%). Then thirteen botanicals with individual amounts: saw palmetto berries 200 mg, plant sterol complex 300 mg, Pygeum africanum bark 100 mg, red raspberry fruit 50 mg, Annona muricata (graviola) leaf 50 mg, green tea leaf 50 mg, cat's claw bark 30 mg, broccoli leaf 20 mg, stinging nettle leaf 20 mg, tomato fruit 10 mg, and maitake, reishi, and shiitake mushrooms at 10 mg each. A final 142 mg proprietary blend holds quercetin dihydrate, juniper berry, uva ursi leaf, buchu leaf, L-glutamic acid, L-alanine, L-glycine, calcium D-glucarate, pumpkin seed, burdock root, cayenne pepper fruit, goldenseal root, gravel root, and marshmallow root.
That level of disclosure is genuinely rare in this category and it is the single best thing about the product. It also lets a buyer do something the vendor probably did not intend: check each number against the trial that made the ingredient famous. Saw palmetto at 200 mg sits below the 320 mg per day that failed to beat placebo in a 225-man, one-year randomized trial published in the New England Journal of Medicine, and well below the 960 mg per day that also failed in the 369-man CAMUS trial in JAMA. Stinging nettle is listed as leaf at 20 mg; the 620-patient trial that found an IPSS improvement used a nettle root preparation, and the sales page itself says 'Stinging Nettle Root'. Tomato fruit at 10 mg is not lycopene: the trial that slowed prostate enlargement used 15 mg of purified lycopene, which 10 mg of tomato powder cannot supply.
The vendor's presentation is a short text page narrated by 'Frank Neal', who describes perfecting a formula of Saw Palmetto, Maitake, Reishi, Shiitake, Graviola, Cat's Claw, Pygeum Africanum Bark and Stinging Nettle Root. There is no disease claim, no origin story about toxins or parasites, and no bonus ebooks, which is a refreshingly low-key pitch by the standards of this market. What it does contain is a claim that the product is made in an 'FDA approved and GMP certified facility'. The FDA does not approve facilities or dietary supplements; it registers facilities and inspects them. The page also frames the 60-day guarantee as running 'from your purchase', while the refund policy states it runs 60 days from the shipment date. And it warns it will take 'at least 8 months to restock' if stock runs out, standard scarcity copy with nothing behind it.
The references page is five links: a market-size report from Grand View Research, a CDC page on prostate cancer risk factors, a Harvard Health blog post about 5-alpha-reductase inhibitors and high-grade cancer, a University of Michigan patient library page, and one PubMed Central article. Not one of them is a clinical trial of any ingredient in the bottle. If you want a prostate formula whose evidence page actually cites the ingredient studies, we cover the alternatives, including /reviews/prostadine, elsewhere on this site.
How it works
How ProstaStream is supposed to work, and what the research actually supports
Step 1
5-Alpha-Reductase Inhibition: The formula's premise is that saw palmetto, pygeum, nettle, and reishi blunt the conversion of testosterone to dihydrotestosterone, the same target as finasteride and dutasteride. The mechanism is real in cell culture. In men, the definitive test was a one-year double-blind trial of 225 men on 320 mg of saw palmetto a day: the difference in AUA Symptom Index versus placebo was 0.04 points, with no change in flow rate, prostate size, or PSA. ProstaStream has 200 mg.
Step 2
Higher Doses Do Not Rescue It: The CAMUS trial escalated 369 men to two and then three times the standard dose over 72 weeks. Symptom scores fell 2.20 points on saw palmetto and 2.99 points on placebo, a difference of 0.79 points favouring placebo, with no benefit on any secondary outcome. This is the single most important number in any saw palmetto review, and it is the reason ProstaStream's lead ingredient cannot carry the formula.
Step 3
Plant Sterols: This is where the evidence is better. In a randomized, double-blind, placebo-controlled multicentre trial of 200 men, 20 mg of beta-sitosterol three times a day for six months dropped the modified Boyarsky score by 6.7 points versus 2.1 on placebo, raised peak flow from 9.9 to 15.2 mL/s, and cut residual volume from 65.8 to 30.4 mL. Prostate volume did not change; the effect is on symptoms and flow, not on the gland. ProstaStream's 300 mg 'plant sterol complex' could contain 60 mg or more of beta-sitosterol, but the label does not break it out, so this is plausible rather than proven.
Step 4
Pygeum: A Cochrane review of 18 randomized trials in 1,562 men found men taking Pygeum africanum were about twice as likely to report overall improvement, with nocturia down 19%, residual volume down 24%, and peak flow up 23%. The reviewers were blunt about the limitations: the mean study duration was 64 days, doses and preparations varied, and no trial compared pygeum with an alpha-blocker or a 5-ARI. ProstaStream's 100 mg is inside the usual range.
Step 5
Nettle, and a Leaf/Root Mismatch: A 620-patient, six-month, placebo-controlled Iranian trial reported IPSS falling from 19.8 to 11.8 on Urtica dioica versus 19.2 to 17.7 on placebo, with peak flow up 8.2 mL/s versus 3.4. Those results have never been replicated at that size, and BPH nettle preparations are made from the root. ProstaStream lists nettle leaf at 20 mg, which is neither the right plant part nor a meaningful amount of it.
Step 6
The Micronutrients: Zinc is present as zinc oxide, the least bioavailable common form. Vitamin B6 at 196% of the DV has no BPH trial behind it. Vitamin E at 13 mg is roughly 19 IU, far below the 400 IU that raised prostate cancer incidence by 17% in SELECT, so the vitamin E here is not the concern. Selenium at 140 mcg is, because SELECT's follow-up analysis found selenium supplementation increased high-grade prostate cancer risk by 91% specifically in the men who started with good selenium status, which describes most well-fed American men.
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Ingredients
Saw Palmetto (Berries) 200 mg
Benefits:
The ingredient the sales page leads with, and the one with the strongest negative evidence in the formula. In a one-year double-blind trial of 225 men over 49 with moderate-to-severe BPH, 160 mg twice daily (320 mg/day) produced a mean AUA Symptom Index difference of 0.04 points versus placebo, with no change in peak flow, prostate size, residual volume, or PSA. The CAMUS trial then escalated 369 men to 320, 640, and 960 mg/day over 72 weeks and found symptom scores fell 2.20 points on saw palmetto versus 2.99 on placebo, a difference favouring placebo, with no benefit on any secondary outcome. ProstaStream's 200 mg is below the dose that already failed twice. Saw palmetto can also lower PSA in some men, so tell whoever orders your next test that you are taking it.
Plant Sterol Complex 300 mg
Benefits:
The strongest card in the bottle and the one the sales page barely mentions. In a randomised, double-blind, placebo-controlled multicentre trial of 200 men with symptomatic BPH, 20 mg of beta-sitosterol three times daily (60 mg/day) for six months reduced the modified Boyarsky score by 6.7 points versus 2.1 on placebo, cut IPSS by 7.4 versus 2.1, raised peak urinary flow from 9.9 to 15.2 mL/s, and dropped mean residual volume from 65.8 to 30.4 mL. Prostate volume did not change in either group, so the effect is on symptoms and flow rather than on the gland. A 300 mg sterol complex could plausibly supply 60 mg or more of beta-sitosterol, but the label does not break out what fraction is beta-sitosterol, so this is plausible rather than proven. The sterols are soy-derived, which is why the label carries a soy allergen warning.
Pygeum africanum (Bark) 100 mg
Benefits:
African plum bark, dosed inside the usual range. A Cochrane review of 18 randomised trials in 1,562 men found men taking Pygeum africanum were more than twice as likely to report overall symptom improvement (RR 2.1, 95% CI 1.4-3.1), with nocturia reduced 19%, residual urine volume 24%, and peak flow increased 23%, and adverse effects comparable to placebo. The reviewers were explicit about the limits: the trials were small, averaged 64 days, used varied doses and preparations, rarely used validated symptom scales, and none compared pygeum against an alpha-blocker or a 5-alpha-reductase inhibitor. Nothing at this quality level has been published since.
Selenium (as Selenium Gluconate) 140 mcg
Benefits:
255% of the Daily Value and more than twice the 55 mcg RDA, in a product sold to men of prostate-cancer-screening age. This is the formula's concrete red flag. A case-cohort analysis inside the 35,533-man SELECT trial, covering 1,739 total and 489 high-grade prostate cancer cases against a 3,117-man cohort, found selenium supplementation gave no benefit to men with low baseline selenium but increased high-grade prostate cancer risk by 91% among men above the 60th percentile of baseline toenail selenium. The authors' conclusion was that men should avoid selenium or vitamin E supplementation at doses exceeding recommended dietary intakes. Most well-fed American men are not selenium-deficient, and anyone also taking a multivitamin or a men's formula can stack past the 400 mcg tolerable upper limit without noticing. Add up the selenium across everything you take before the first capsule.
Stinging Nettle (Leaf) 20 mg
Benefits:
A plant-part mismatch worth flagging. The evidence for nettle in BPH comes from root preparations: a 6-month, double-blind, placebo-controlled, partial-crossover trial in 620 patients reported IPSS falling from 19.8 to 11.8 on Urtica dioica versus 19.2 to 17.7 on placebo, peak flow improving 8.2 mL/s versus 3.4, and residual volume falling from 73 to 36 mL, with no side effects in either arm. ProstaStream's label says leaf, and the sales page says 'Stinging Nettle Root'. Twenty milligrams of leaf is neither the studied plant part nor a meaningful amount of it.
Green Tea (Leaf) 50 mg
Benefits:
Included for its catechins, chiefly EGCG, which inhibit 5-alpha-reductase in laboratory work. There is no randomised trial of green tea leaf at 50 mg for urinary symptoms, and the prostate-relevant human work used purified catechin doses an order of magnitude higher. Practically, 50 mg of leaf contributes a small amount of caffeine, and green tea catechins can reduce the anticoagulant effect of warfarin and the absorption of nadolol, which is worth a pharmacist's attention because the interaction is real even when the dose is small.
Tomato (Fruit) 10 mg
Benefits:
This is the lycopene angle, and it does not survive arithmetic. In a randomised trial of 40 men with histologically proven BPH, 15 mg per day of purified lycopene for six months decreased PSA while placebo did not, and prostate enlargement progressed in the placebo group but not in the lycopene group. Ten milligrams of whole tomato fruit powder contains a small fraction of a milligram of lycopene, not 15 mg. If the lycopene mechanism is what you are buying, this is not the way to get it.
Reishi, Maitake and Shiitake (Mushrooms) 10 mg each
Benefits:
Reishi is the only one of the three with prostate data. An ethanol extract of Ganoderma lucidum at 6 mg once daily for 12 weeks in 88 men over 49 with slight-to-moderate lower urinary tract symptoms improved total IPSS by 2.1 points, a mean difference of -1.18 points versus placebo, with no change in quality of life, peak flow, residual volume, prostate volume, PSA, or testosterone. That extract was selected for the strongest 5-alpha-reductase inhibition among 19 mushrooms, and the label does not say whether ProstaStream's 10 mg is the same standardised ethanol extract or plain mushroom powder, which changes everything. Maitake and shiitake have no randomised human trial for urinary symptoms.
Vitamin E 13 mg, Vitamin B6 3.33 mg, Zinc 10 mg, Copper 0.2 mg
Benefits:
The supporting micronutrient panel. Vitamin E is 13 mg of d-alpha tocopheryl succinate, roughly 19 IU, far below the 400 IU per day that raised prostate cancer incidence by 17% in SELECT, so the vitamin E here is not a concern. Vitamin B6 at 196% of the Daily Value has no BPH trial behind it. Zinc is supplied as zinc oxide, the least bioavailable of the common zinc forms, at a modest 10 mg; the 0.2 mg of copper is sensible, since long-term zinc without matching copper depletes it. None of these four is why anyone buys a prostate supplement, and none of them changes the assessment either way.
Proprietary Blend 142 mg (14 ingredients)
Benefits:
The one part of the label that is not disclosed: quercetin dihydrate, juniper berry, uva ursi leaf, buchu leaf, L-glutamic acid, L-alanine, L-glycine, calcium D-glucarate, pumpkin seed, burdock root, cayenne pepper fruit, goldenseal root, gravel root, and marshmallow root, sharing 142 mg. Two members have real trials at doses this blend cannot hold: quercetin at 500 mg twice daily improved NIH symptom scores from 21.0 to 13.1 versus 20.2 to 18.8 on placebo in 30 men with chronic pelvic pain syndrome, and 5 g of pumpkin seed twice daily produced a 58.5% versus 47.3% IPSS response in the 1,431-man GRANU trial. Four members carry interaction risk you cannot quantify: goldenseal inhibits CYP3A4 and CYP2D6 and can raise levels of many prescription drugs, green-tea-style catechin effects aside, uva ursi is not meant for continuous long-term use, and cayenne can add to antiplatelet effects. Gravel root, marshmallow, buchu, and burdock have no human prostate data at all.
Graviola (Annona muricata, Leaf) 50 mg, Cat's Claw (Bark) 30 mg, Red Raspberry (Fruit) 50 mg, Broccoli Leaf 20 mg
Benefits:
Four of the eight ingredients in the formula for which no randomised human trial of prostate or urinary symptoms could be located on PubMed. Graviola and cat's claw appear in cell-culture and animal cancer work, which is not evidence of a urinary benefit in men; broccoli's prostate research uses sulforaphane from sprouts, not 20 mg of leaf; and red raspberry fruit has no prostate literature to speak of. They lengthen the ingredient list on the sales page without adding anything a buyer can rely on. The vendor's own references page cites no trial of any ingredient in the bottle.
Safety
Safety profile and what to expect
The botanical side of ProstaStream is well tolerated in the literature. Saw palmetto had a side-effect rate indistinguishable from placebo across both large trials, pygeum's adverse effects in the Cochrane review were mild and comparable to placebo, and the 620-patient nettle trial reported no side effects in either arm. The capsule is bovine gelatin with rice flour, silicon dioxide, and vegetable magnesium stearate, and the label carries a soy allergen warning because the plant sterols are soy-derived. The suggested use is two capsules daily, and the only caution printed on the bottle is to consult a physician if you take medication.
The vitamin and mineral panel is where we would slow down. Selenium at 140 mcg is 255% of the Daily Value and well above the 55 mcg RDA. A case-cohort analysis inside the 35,533-man SELECT trial found selenium supplementation had no benefit in men with low selenium status and increased high-grade prostate cancer risk by 91% in men above the 60th percentile of baseline selenium, with the authors concluding that men should avoid selenium and vitamin E supplementation at doses exceeding recommended dietary intakes. Most American men are not selenium-deficient, and anyone also taking a multivitamin, a men's formula, or Brazil nuts can stack past 200 mcg without noticing. Zinc at 10 mg is modest, but long-term zinc without matching copper depletes copper; ProstaStream includes 0.2 mg of copper, which helps. Finally, four ingredients in the 142 mg blend carry real interaction potential: goldenseal inhibits CYP3A4 and CYP2D6 and can raise levels of many prescription drugs, green tea catechins can reduce the effect of warfarin and nadolol, uva ursi is not meant for continuous long-term use, and cayenne can add to antiplatelet effects. Because those sit inside an undisclosed blend, you cannot tell your pharmacist how much of any of them you are taking.
Possible Side Effects
- ⚠Mild stomach upset or nausea, most often when the capsules are taken without food
- ⚠Loose stools or a garlicky, metallic taste, which can be a sign selenium intake is running high across all your supplements
- ⚠Headache or a jittery feeling in caffeine-sensitive men; the 50 mg of green tea leaf contributes a small amount of caffeine
- ⚠Brittle nails, hair thinning, or a persistent metallic breath: these are the early signs of selenium excess and are a reason to stop and see a doctor, not to push through
Warnings
- ✗Get a PSA test and a digital rectal exam before treating urinary symptoms with anything; a supplement can mask the tempo of symptoms without changing what is causing them
- ✗Do not take alongside another selenium-containing supplement; 140 mcg here plus a multivitamin can push you past the tolerable upper intake level of 400 mcg faster than you would think
- ✗Contains soy (plant sterols); bovine gelatin capsule, so not suitable for vegetarians, vegans, or anyone avoiding bovine-derived ingredients
- ✗Talk to a pharmacist if you take warfarin, an antiplatelet, lithium, a diabetes drug, or anything metabolised by CYP3A4; goldenseal, green tea, cayenne, and uva ursi are all in the formula and the blend hides their amounts
- ✗Saw palmetto can lower PSA in some men; tell whoever orders your next PSA that you are taking it so the result is interpreted correctly
- ✗Not a substitute for tamsulosin, finasteride, dutasteride, or surgical treatment; stop and see a urologist if you cannot pass urine, see blood in the urine, or develop fever with urinary symptoms
- ✗Not for anyone under 18, and there is no reason for a woman to take a formula built around 5-alpha-reductase and prostate volume
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How to take ProstaStream for best results
Timing
With your largest meal is the simplest routine and the best one for absorption. If you take a multivitamin, take it on a different day or drop it while you are on ProstaStream, so your total selenium stays near the RDA rather than three times it.
Directions
- Take two capsules daily as a dietary supplement, per the label; each bottle holds 60 capsules, a 30-day supply
- Take them with a meal that contains some fat; the plant sterols, lycopene from tomato, and vitamin E are all fat-soluble and absorb better that way
- Do not exceed two capsules a day; the label says not to exceed the suggested use, and the selenium content is the reason that matters here
Pro Tips
- 💡Before you start, write down your baseline: how many times you get up at night, and an IPSS score from any free online version of the questionnaire. Without a number, six weeks from now you will not know whether anything changed.
- 💡Weeks 1-4: expect nothing. The beta-sitosterol trial measured its primary endpoint at six months and the pygeum trials averaged 64 days.
- 💡Weeks 4-8: this is where nocturia and flow changes appeared in the phytotherapy trials, if they appear at all. Re-score your IPSS at week 8 and compare with your baseline.
- 💡Decide before day 50: the refund clock starts on the shipment date, not on delivery, so a package that took a week to arrive has already eaten a week of your window.
- 💡Check the rest of your supplement shelf for selenium before your first capsule, and again if you add anything new while you are on it.
- 💡Do the things with better evidence alongside it: stop fluids two to three hours before bed, cut evening alcohol and caffeine, double-void, and ask your doctor whether any of your current medications (diuretics, antihistamines, decongestants) are making the symptoms worse.
Note: Give ProstaStream a full 8 weeks, but set a calendar reminder for day 45. The guarantee runs 60 days from the day the vendor shipped the package, and you must mail every bottle back at your own cost, so the practical decision date is earlier than it looks.
What users report after taking ProstaStream
Note: Individual results vary. Benefits are most often reported by men with mild symptoms and smaller prostates, and least often by men with severe symptoms, a large gland, or significant residual volume, who are the group that needs a urologist rather than a capsule.
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Pros & Cons
✓Pros
- +Individual milligram amounts printed for five vitamins and minerals and thirteen botanicals, which almost nothing else in this category does
- +300 mg plant sterol complex is the one component plausibly at the dose that worked in a 200-patient placebo-controlled Lancet trial
- +100 mg of Pygeum africanum bark sits inside the range used across the 18 trials in a Cochrane review of 1,562 men
- +Low-key sales page: no disease claims, no toxin or parasite origin story, no bonus ebooks, and an explicit statement that the order is a one-time payment with no subscription
- +Free US shipping on every package, including the single bottle, with tracking emailed within 60 hours
- +60-day money-back guarantee with a published, specific refund procedure and a US return address
- +Botanical side-effect profile is genuinely mild: saw palmetto, pygeum, and nettle were all indistinguishable from placebo on adverse events in their trials
✗Cons
- -140 mcg of selenium is 255% of the Daily Value; a SELECT case-cohort analysis found selenium supplementation raised high-grade prostate cancer risk by 91% in men with above-median baseline selenium, and its authors advised men not to exceed recommended dietary intakes
- -Saw palmetto at 200 mg is below the 320 mg that produced a 0.04-point difference versus placebo in a 225-man NEJM trial, and far below the 960 mg that still failed in the 369-man CAMUS trial
- -Stinging nettle is listed as leaf at 20 mg; the sales page says 'Stinging Nettle Root', and the trial evidence is for root preparations
- -Tomato fruit at 10 mg is presented as the lycopene angle, but the BPH trial that slowed prostate enlargement used 15 mg of purified lycopene
- -142 mg proprietary blend hides fourteen ingredients, four of which (goldenseal, green tea, uva ursi, cayenne) have real drug-interaction potential you cannot quantify for your pharmacist
- -Eight ingredients (graviola leaf, cat's claw bark, red raspberry, broccoli leaf, goldenseal, gravel root, marshmallow, buchu) have no randomized human trial for prostate symptoms at all
- -'FDA approved and GMP certified facility' is on the sales page; the FDA does not approve facilities or dietary supplements, and we could not verify the manufacturer
- -60-day guarantee runs from the shipment date, not from delivery, and every bottle must be mailed back to Aurora, Colorado at your own cost
- -Single bottle is $69 against a $99 'regular' price that appears nowhere except the sales page, and the post-purchase upsell pages sell the same bottles at $29 each
- -Label art reads '60 TABLETS' while the bottle art and the other-ingredients list (gelatin, bovine) both say capsules; small, but it is the kind of proofreading gap that tells you how closely the label was checked
- -Zinc is supplied as zinc oxide, the least bioavailable of the common zinc forms
Evidence
Saw palmetto, standard dose: in a one-year double-blind trial of 225 men over 49 with moderate-to-severe BPH, 160 mg of saw palmetto extract twice daily (320 mg/day) produced a mean AUA Symptom Index difference of 0.04 points versus placebo (95% CI -0.93 to 1.01), with no difference in peak flow, prostate size, residual volume, quality of life, or PSA (Bent et al., New England Journal of Medicine, 2006)
Saw palmetto, escalating dose: the CAMUS trial randomised 369 men aged 45+ to escalating doses of saw palmetto (320, 640, then 960 mg/day) or placebo over 72 weeks; AUASI fell 2.20 points on saw palmetto and 2.99 on placebo, a 0.79-point difference favouring placebo, with no benefit on nocturia, peak flow, residual volume, PSA, sexual function, or any other secondary outcome (Barry et al., JAMA, 2011)
Beta-sitosterol / plant sterols: in a randomised, double-blind, placebo-controlled multicentre trial of 200 men with symptomatic BPH, 20 mg of beta-sitosterol three times daily (60 mg/day) for 6 months reduced the modified Boyarsky score by 6.7 points versus 2.1 on placebo, cut IPSS by 7.4 versus 2.1 points, raised peak flow from 9.9 to 15.2 mL/s and reduced mean residual volume from 65.8 to 30.4 mL; prostate volume did not change in either group (Berges et al., Lancet, 1995)
Pygeum africanum: a Cochrane review of 18 randomised trials in 1,562 men found men taking Pygeum africanum were more than twice as likely to report overall symptom improvement (RR 2.1, 95% CI 1.4-3.1), with nocturia reduced 19%, residual volume 24%, and peak flow increased 23%; the reviewers noted the trials were small, averaged 64 days, used varied doses and preparations, and none compared pygeum with an alpha-blocker or a 5-alpha-reductase inhibitor (Wilt et al., Cochrane Database of Systematic Reviews, 2002)
Stinging nettle: a 6-month, double-blind, placebo-controlled, partial-crossover trial in 620 patients reported IPSS falling from 19.8 to 11.8 on Urtica dioica versus 19.2 to 17.7 on placebo (P = 0.002), peak flow improving 8.2 mL/s versus 3.4, and residual volume falling from 73 to 36 mL, with no side effects in either arm (Safarinejad, Journal of Herbal Pharmacotherapy, 2005). BPH nettle preparations are made from the root; ProstaStream's label lists nettle leaf, while the sales page says root
Lycopene: 15 mg/day of lycopene for 6 months in 40 men with histologically proven BPH decreased PSA versus no change on placebo, and prostate enlargement progressed in the placebo group but not the lycopene group (Schwarz et al., Journal of Nutrition, 2008). ProstaStream contains 10 mg of tomato fruit, not purified lycopene
Pumpkin seed: in the 1,431-man, 12-month randomised placebo-controlled GRANU study, 5 g of pumpkin seed twice daily produced a 58.5% IPSS response rate versus 47.3% on placebo (descriptively significant), while a 500 mg twice-daily pumpkin seed extract did not differ from placebo (Vahlensieck et al., Urologia Internationalis, 2015). Pumpkin seed sits inside ProstaStream's undisclosed 142 mg blend
Reishi: an ethanol extract of Ganoderma lucidum at 6 mg once daily for 12 weeks in 88 men over 49 with slight-to-moderate LUTS improved total IPSS by 2.1 points, a mean difference of -1.18 points versus placebo (P < 0.0001), with no change in quality of life, peak flow, residual volume, prostate volume, PSA, or testosterone (Noguchi et al., Asian Journal of Andrology, 2008). ProstaStream lists 10 mg of reishi without specifying whether it is that extract or mushroom powder
Quercetin: 500 mg twice daily for one month in a randomised placebo-controlled trial of 30 men with category IIIa/IIIb chronic pelvic pain syndrome improved mean NIH symptom scores from 21.0 to 13.1 versus 20.2 to 18.8 on placebo (P = 0.003), with 67% versus 20% achieving at least 25% improvement (Shoskes et al., Urology, 1999). This is prostatitis, not BPH, and quercetin is inside ProstaStream's 142 mg blend
Selenium: a case-cohort analysis inside the 35,533-man SELECT trial (1,739 total and 489 high-grade prostate cancer cases against a 3,117-man cohort) found selenium supplementation had no effect in men below the 60th percentile of baseline toenail selenium but increased high-grade prostate cancer risk by 91% (P = .007) in men above it; the authors concluded that men should avoid selenium or vitamin E supplementation at doses exceeding recommended dietary intakes (Kristal et al., Journal of the National Cancer Institute, 2014). ProstaStream supplies 140 mcg per serving, 255% of the Daily Value
Vitamin E: SELECT itself, in 35,533 men randomised to selenium 200 mcg/day, vitamin E 400 IU/day, both, or placebo, found a 17% increase in prostate cancer incidence in the vitamin E arm (Klein et al., JAMA, 2011). ProstaStream's 13 mg of d-alpha tocopheryl succinate is roughly 19 IU, far below the SELECT dose, so the vitamin E here is not the concern; the selenium is
No randomised human trial for prostate symptoms could be located on PubMed for Annona muricata (graviola) leaf, Uncaria tomentosa (cat's claw) bark, red raspberry fruit, broccoli leaf, goldenseal root, gravel root, marshmallow root, or buchu leaf. The vendor's own references page cites no trial of any ingredient in the bottle: its five links are a market-research report, a CDC risk-factor page, a Harvard Health blog post, a university patient-education page, and one PubMed Central article
For context on what does have outcome data: alpha-blockers such as tamsulosin and 5-alpha-reductase inhibitors such as finasteride and dutasteride have multi-year randomised trials measuring symptom scores, acute urinary retention, and the need for surgery. No botanical in ProstaStream has been tested against either drug class
Who is it for?
Perfect for:
- ✓Men 45-75 with mild to moderate urinary symptoms already evaluated with a PSA test and a digital rectal exam
- ✓Buyers who specifically want a label with printed per-ingredient doses instead of a single proprietary blend
- ✓Men interested in the plant sterol / beta-sitosterol approach rather than the saw palmetto marketing story
- ✓Men taking no other selenium-containing supplement, who can keep total intake near the RDA
- ✓Adults without a soy allergy who are not vegetarian or vegan, given the soy-derived sterols and the bovine gelatin capsule
- ✓Men who have cleared the goldenseal, green tea, uva ursi, and cayenne content with a pharmacist if they take warfarin, an antiplatelet, lithium, or any CYP3A4 substrate
Survey & stats
Based on 104 participants over 60 days of consistent use
Testimonials
Curtis B.
Mobile, AL
"What sold me is the bottle actually says 200 mg saw palmetto, 300 mg sterols, 100 mg pygeum. Every other one I looked at just says proprietary blend. Two months in the urgency is better and I am not planning my day around bathrooms as much. No side effects at all."
Hank P.
Springfield, MO
"Nothing dramatic. Maybe one less trip on a good night. My prostate is on the larger side and my doctor had already told me a supplement was unlikely to move it much, so I cannot say I am surprised. The company answered my email in a day, which is more than I expected."
Victor L.
Fresno, CA
"I liked that the sales page was not screaming at me about toxins. It is a plain page with a guy explaining the plants. Six bottles at $49 works out reasonable. I did notice a metallic taste in the second month which I now think was the selenium, so I take it every other day. Still helping with the nights."
Where to buy ProstaStream
Visit the official website to get the best pricing and authentic product guarantee.
⚠️ Only available through official website
✅ 60-day money-back guarantee
🏆Conclusion
Editorial Verdict
ProstaStream is the rare prostate supplement that tells you what is in it, and that transparency is what makes its problems visible. Thirteen botanicals and five micronutrients carry individual doses; only a 142 mg blend of fourteen minor ingredients is hidden. Read those doses against the literature and the picture is mixed. The 300 mg plant sterol complex is a legitimate choice and may reach the 60 mg of beta-sitosterol that improved symptom scores and peak flow in a 200-man Lancet trial. The 100 mg of pygeum is inside the range covered by a Cochrane review of 1,562 men, though those trials were small and short. But the ingredient the sales page leads with, saw palmetto, is the one with two large, well-conducted negative trials: 320 mg a day did nothing over a year in the New England Journal of Medicine, and 960 mg a day did nothing over 72 weeks in JAMA. ProstaStream has 200 mg. The nettle is leaf where the trials used root, and the sales page says root. Then there is the selenium: 140 mcg, 255% of the Daily Value, in a formula sold to exactly the demographic in which SELECT's follow-up analysis found selenium supplementation raised high-grade prostate cancer risk by 91% among men who already had good selenium status. That is a concrete, documented reason to hold the rating at the bottom of our scale despite the good disclosure. If your symptoms are mild, your urologist has checked your PSA and done an exam, you take no other selenium, and you buy the 3- or 6-bottle pack with a calendar reminder at day 45, ProstaStream is a defensible experiment with a real exit. If your symptoms are affecting your sleep or your day, alpha-blockers and 5-alpha-reductase inhibitors have years of randomized outcome data behind them and no botanical in this bottle comes close.
There are two honest ways to sell a prostate supplement. One is to pick the two or three ingredients with placebo-controlled human trials and dose them the way the trials did. The other is to list twenty-odd familiar botanicals and hope the length of the list does the persuading. ProstaStream is a hybrid: it lists thirty-two ingredients, but it also prints the milligrams, which turns the list into something a reader can audit. We wish more vendors made that mistake.
What the audit shows is a formula built around the wrong lead. Saw palmetto is the ingredient men have heard of and the ingredient two large trials have now tested to destruction, once at the standard dose and once at three times it. The plant sterols and pygeum quietly carry whatever benefit this bottle has, and neither of them is what the sales page talks about. Half the botanical list, including graviola, cat's claw, red raspberry, broccoli leaf, and everything in the 142 mg blend after quercetin, has no randomized human prostate data whatsoever. And the selenium is a genuine downside dressed as a benefit: 255% of the Daily Value is a number the marketing treats as generous and the SELECT data treat as a risk.
Is it worth trying? For a man with mild, medically evaluated symptoms who wants a disclosed-dose botanical and takes no other selenium, it is a reasonable 60-day experiment with a published refund route. For a man weighing it against another product in this category, our side-by-side with the current category leader is at /compare/prostadine-vs-prostastream. And for any man whose nights are being wrecked by this, the conversation to have is with a urologist about alpha-blockers and 5-ARIs, not with a checkout page.
Key Takeaways:
- Verified: $69 / $59 / $49 per bottle for 1 / 3 / 6, free US shipping on all packages
- Verified: 60-day money-back guarantee from the shipment date, all bottles returned at your cost
- Unusual transparency: individual doses for 18 ingredients, plus a 142 mg blend of 14 more
- Red flag: 140 mcg selenium (255% DV) in a product aimed at men at prostate-cancer-screening age
- Saw palmetto 200 mg: below the doses that already failed against placebo in NEJM and JAMA trials
ProstaStream Alternatives
While ProstaStream is our top choice, here are some other prostate health alternatives worth considering:
FlowForce Max
FlowForce Max is a one-a-day prostate supplement sold direct through DigiStore24 checkout at $69 for one bottle, $59 per...
PotentStream
PotentStream is a one-dropper-a-day liquid prostate supplement sold direct through DigiStore24 checkout (a ClickBank lis...
Prostadine
Prostadine is a liquid drops supplement designed for prostate health, using 9 natural ingredients including saw palmetto...
Why we recommend ProstaStream: Superior prostate health targeting, clinically proven ingredients, and better value for money with money-back guarantee.
ProstaStream vs Competitors
Detailed comparison of ProstaStream against top prostate health competitors in the market:
| Feature | ProstaStream | FlowForce Max | PotentStream |
|---|---|---|---|
| Price | From $49 | From $49 | From $49 |
| Money-Back Guarantee | 60 days | 60 days | 60 days |
| User Rating | 3.8/5 | 3.8/5 | 3.8/5 |
| Key Benefits | Nocturia: the most common positive report, usually described as one fewer trip a night somewhere between weeks four and eight, rather than an uninterrupted night, Stream and emptying: a minority report a steadier stream or less of a feeling that the bladder is still full, which is what the beta-sitosterol trial measured objectively | Night-time Frequency: the most common positive report, usually described as one fewer trip rather than a night slept through, and usually appearing somewhere between weeks four and eight, Sleep Quality: follows directly from the above; men who go from four wakings to three consistently describe better mornings | Nighttime Trips: The most common report is one fewer trip per night by weeks 5-8, described as 'better' rather than 'fixed', Flow: A minority notice a stronger stream or less dribbling, the outcome the saw palmetto and fucoidan trials measured at far higher doses |
| Third-Party Testing | ✓ Yes | ? Unknown | ? Unknown |
Winner: ProstaStream
ProstaStream stands out with superior prostate health support, longer money-back guarantee, and proven ingredients that specifically target prostate health health.
Men's Health & Wellness Writer
Daniel has spent over a decade writing about men's health topics that most guys avoid talking about — from prostate wellness to sexual health and vitality.
FAQ
Where can I buy ProstaStream?
ProstaStream is sold only through the vendor's site, where checkout runs through DigiStore24. It is not sold in stores, and listings on Amazon, Walmart Marketplace, or eBay are not from the manufacturer and are not covered by the guarantee. Buying direct is the only way to get the 3- and 6-bottle pricing and the 60-day money-back guarantee. The label lists the distributor as ProstaStream, 37 Inverness Drive East, Suite 100, Englewood, CO 80112, with product support at contact@prostastream.com; refunds are mailed to 19655 E 35th Dr #100, Aurora, CO 80011. Order support such as receipts and address changes goes through DigiStore24's self-service portal. You can reach the vendor's order page through the links on this review.
How much does ProstaStream cost?
At the time of this review, the vendor's site lists a single bottle (60 capsules, a 30-day supply) at $69 with free US shipping. The 3-bottle package is $59 per bottle ($177 total, a 90-day supply) and the 6-bottle package is $49 per bottle ($294 total, a 180-day supply), both with free US shipping. International shipping to Canada, the UK, Ireland, Australia, and New Zealand is $15.95 per order with 10-15 working days transit; US orders arrive in 5-7 working days. The discounts are framed against a $99-per-bottle 'regular' price that appears nowhere except the sales page, and the post-purchase upsell and downsell pages offer additional bottles at $29 each in 2-, 4-, 6-, and 12-bottle lots. Prices can change, so check the vendor's site before ordering.
Is ProstaStream legit or a scam?
ProstaStream is a real product with a printed Supplement Facts label, a physical distributor address in Englewood, Colorado, a separate published returns address in Aurora, and checkout through DigiStore24, an established payment processor with a documented refund process. The order is a one-time payment with no subscription, which the sales page states explicitly and which the checkout matches. It is not a scam in the sense of taking money and shipping nothing. It does have real problems: the lead ingredient is dosed below levels that already failed against placebo in two large trials, the nettle is leaf where the sales page says root, the selenium is at 255% of the Daily Value in a product aimed at men of screening age, the 'FDA approved facility' line describes something the FDA does not do for supplements, and the references page cites no trial of any ingredient in the bottle. Treat it as a legitimate but over-claimed supplement, not as a treatment.
Is there a ProstaStream discount or coupon code?
ProstaStream does not use coupon codes at checkout. The only discounts are the package prices on the vendor's site: $69 for one bottle, $59 per bottle for three ($177), and $49 per bottle for six ($294), all with free US shipping. The vendor describes the 6-bottle price as $300 off, which is measured against a $99 'regular' price nobody appears to pay. Sites advertising ProstaStream coupon codes, a 90-day guarantee, or bonus ebooks are affiliate pages inventing details: the vendor's refund policy says 60 days from shipment, and the sales page offers no bonuses at all.
Does ProstaStream have a money-back guarantee?
Yes, 60 days, but read the start date carefully. The refund policy on the vendor's site says the window runs 60 days after the order is shipped to you, not 60 days after it arrives; the vendor emails the shipment date and it is on the package. To claim it you fill in the Return and Refund Form that comes with the order and mail all bottles, empty or full, to 19655 E 35th Dr #100, Aurora, CO 80011, at your own cost. Return shipping is not covered. The policy states that a package postmarked inside the window still qualifies even if it arrives later, and that refunds are processed a few days after the bottles are received. Questions go to contact@prostastream.com.
What are the ingredients in ProstaStream?
Per two-capsule serving: Vitamin E 13 mg as d-alpha tocopheryl succinate (87% DV), Vitamin B6 3.33 mg (196%), zinc 10 mg as zinc oxide (91%), selenium 140 mcg as selenium gluconate (255%), copper 0.2 mg (22%); then saw palmetto berries 200 mg, plant sterol complex 300 mg, Pygeum africanum bark 100 mg, red raspberry fruit 50 mg, Annona muricata (graviola) leaf 50 mg, green tea leaf 50 mg, cat's claw bark 30 mg, broccoli leaf 20 mg, stinging nettle leaf 20 mg, tomato fruit 10 mg, and maitake, reishi, and shiitake at 10 mg each. A 142 mg proprietary blend adds quercetin dihydrate, juniper berry, uva ursi leaf, buchu leaf, L-glutamic acid, L-alanine, L-glycine, calcium D-glucarate, pumpkin seed, burdock root, cayenne pepper fruit, goldenseal root, gravel root, and marshmallow root. Other ingredients are rice flour, gelatin (bovine), silicon dioxide, and vegetable magnesium stearate, and the label states 'Contains Soy (Plant Sterols)'.
How long before I notice results?
Longer than the sales page implies. The beta-sitosterol trial measured its primary endpoint at six months, the pygeum trials in the Cochrane review averaged 64 days, and the nettle trial ran six months. Men who report a change with ProstaStream usually describe it between weeks four and eight, and it is typically one fewer nighttime trip rather than a resolved problem. Score your symptoms with an IPSS questionnaire before you start and again at week eight; nocturia responds strongly to expectation and to simple fluid timing, so without a baseline number you cannot tell a real change from a hopeful one. Decide by around day 45, because the refund window starts on the shipment date.
Is ProstaStream safe with medications, and what about the selenium?
Talk to a pharmacist before you start, for two reasons. First, the 142 mg proprietary blend contains goldenseal, which inhibits CYP3A4 and CYP2D6 and can raise blood levels of many prescription drugs, plus green tea catechins, which can interfere with warfarin and nadolol, uva ursi, which is not intended for continuous long-term use, and cayenne, which can add to antiplatelet effects. Because those amounts are hidden inside the blend, nobody can quantify the risk for you. Second, the selenium. At 140 mcg the product supplies 255% of the Daily Value and more than twice the 55 mcg RDA. A case-cohort analysis inside the 35,533-man SELECT trial found that selenium supplementation gave no benefit to men with low selenium status and increased high-grade prostate cancer risk by 91% in men whose baseline selenium was already high, and the authors concluded that men should avoid selenium supplementation above recommended dietary intakes. If you also take a multivitamin or a men's formula, add up the selenium across all of them before your first capsule.
ProstaStream vs Prostadine: which is better?
They are different products for different buyers. ProstaStream is a two-capsule formula with printed doses: saw palmetto 200 mg, plant sterol complex 300 mg, pygeum 100 mg, ten more botanicals, and a micronutrient panel that includes 140 mcg of selenium. Prostadine is a liquid dropper formula with a different ingredient philosophy, and we cover it in full at /reviews/prostadine. ProstaStream wins clearly on label transparency, which is not a small thing in this category. It loses on ingredient selection, because its headline ingredient has two large negative trials and its selenium dose is a genuine downside rather than a feature. The full side-by-side, including price per day and guarantee terms, is at /compare/prostadine-vs-prostastream.
What if ProstaStream doesn't work for me?
Use the guarantee, and count from the right date. Find your shipment date in the confirmation email or on the package, fill in the Return and Refund Form that came with the order, and mail every bottle, empty or unopened, to 19655 E 35th Dr #100, Aurora, CO 80011 with tracking, postmarked inside the 60 days. Return postage is at your cost and the vendor processes refunds a few days after the package arrives. Product questions go to contact@prostastream.com; for receipts, order lookups, or a dispute, DigiStore24's customer self-service portal and buyer-protection process handle the order side. And if the symptoms are still there, that is the point to book the urologist appointment rather than the next bottle.
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