Menovelle Review: Can a 1,330 mg Ten-Mushroom Blend Sold as a Menopause Formula Justify $79 a Bottle? (2026)
Menovelle is a two-capsule-a-day menopause supplement sold direct through DigiStore24 checkout at $158 for two bottles ($79 each, plus $9.99 shipping), $207 for three ($69 each), and $294 for six ($49 each), with a 60-day money-back guarantee and no single-bottle option. The Supplement Facts panel lists 266 mg each of Cordyceps sinensis mycelium powder, reishi extract, shiitake extract, and lion's mane, plus a 266 mg proprietary blend of maitake, turkey tail, chaga, royal sun agaricus (Agaricus blazei), white button mushroom, and wood ear fungus, 1,330 mg in total. We read the vendor's text presentation, the label, the refund and shipping policies, and the references page, decoded the pricing configuration on the sales page, and checked each ingredient against PubMed. The formula is a stock ten-mushroom complex: the same 266 mg x 4 plus 266 mg proprietary-blend panel, down to the ingredient order and botanical names, is sold on Amazon as a generic '10 Mushroom Blend Complex' for immune and cognitive support. None of the ten mushrooms has a placebo-controlled trial for hot flashes, night sweats, or menopausal weight gain, and the 'estro-gene' and 'estrogen-eating fat cells' story on the sales page is supported on the vendor's own references page only by rat studies and news articles.
Diana Caldwell
Women's Hormone & Menopause Nutrition Specialist
Last updated: September 6, 2026
Disclosure: This review contains affiliate links. If you purchase through our links, we may earn a commission at no extra cost to you. Read our affiliate disclosure and editorial policy.
Women's Hormone & Menopause Nutrition Specialist
Diana writes about perimenopause, menopause, and women's hormonal health, translating clinical endocrinology into practical guidance for women navigating the hormonal transitions of their 40s, 50s, and beyond.
At a glance
Best for
- Women 45-60 with mild perimenopausal mood, focus, or energy complaints who were already considering a reishi or lion's mane supplement
- People who want ten mushrooms in one capsule rather than buying reishi, lion's mane, and cordyceps separately
- Anyone who has ruled out hormone therapy and fezolinetant with their doctor and is choosing between low-risk supplements with modest expectations
- Buyers who will commit to the 6-bottle order at $49 per bottle so the refund window and the vendor's 3-month recommendation overlap
- Women who value a clean excipient list: cellulose capsule, microcrystalline cellulose, magnesium stearate, and nothing else
Not for
- Anyone with seven or more moderate-to-severe hot flashes a day; those women have three drug classes with phase 3 trial data and no mushroom has any
- Women looking for the phytoestrogen or black-cohosh approach; Menovelle contains neither, only mushrooms
- People on anticoagulants, immunosuppressants, or diabetes medication without pharmacist clearance; reishi and several other mushrooms in the blend interact with all three
- Anyone with a mushroom or mold allergy, or who reacted to shiitake in the past (shiitake dermatitis is well documented)
- Pregnant or nursing women and anyone under 18, per the label
- Anyone expecting the 'estrogen-eating fat cells' story to be biology rather than a sales angle
Menovelle price & where to buy
- Price: from $49 per bottle (single bottle $79) · Save up to $780 on 6 bottles
- Guarantee: 60-day money-back guarantee
- Where to buy: only on the official Menovelle website — not sold in stores, on Amazon or Walmart.
Menovelle still worth it in 2026?
A generic mushroom complex with a menopause label on it: possibly worth a 6-bottle trial for mood and energy if you already wanted a mushroom supplement, not a treatment for hot flashes and not worth $79 a bottle
"I feel a little steadier in the afternoons and my sleep is slightly better. Hot flashes are exactly the same as before. Two months in."
"I took a picture of the label to my pharmacist and she pointed out it is the same mushroom blend they sell for twenty dollars. Nothing to do with estrogen."
"No side effects, easy to take, but I honestly cannot tell you it did anything the placebo would not have done."
- Reishi, lion's mane, shiitake, maitake, and Agaricus blazei each have at least one randomized human trial, and lion's mane has one small trial in menopausal-age women for mood; that is more than most menopause supplements sold this way can say.
- None of those trials measured hot flashes, night sweats, or menopausal weight gain, and the lion's mane trial used 30 women eating mushroom cookies for four weeks; the effect on the Kupperman menopause index was not reported as significant versus placebo.
- The Supplement Facts panel is identical, ingredient for ingredient and milligram for milligram, to a generic ten-mushroom complex sold on Amazon for immune and cognitive support; the 'estro-gene' mechanism exists only on the sales page.
- 60-day money-back guarantee per the vendor's refund policy, counted from delivery; all bottles must be mailed back at your cost to Aurora, Colorado, and the vendor itself recommends 3 months of use before judging.
Best suited to women who wanted a multi-mushroom supplement anyway, are managing mild mood or energy dips rather than frequent hot flashes, and buy the 6-bottle pack so the per-bottle price stops being absurd relative to what the formula is.
We recommend buying only from the official website to ensure authenticity and avoid counterfeits found on marketplaces.
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What is Menovelle?
A two-a-day ten-mushroom complex relabeled as a menopause supplement
Menovelle is a 60-capsule, two-a-day supplement distributed by a company of the same name at 19655 E 35th Dr #100, Aurora, Colorado, and sold through DigiStore24. The Supplement Facts panel lists, per two vegetable capsules: Cordyceps sinensis powder (mycelium) 266 mg, reishi mushroom extract (Ganoderma lucidum, fruit) 266 mg, shiitake mushroom extract (Lentinus edodes, fruit) 266 mg, lion's mane (Hericium erinaceus, fruit) 266 mg, and a 266 mg proprietary blend of maitake (Grifola frondosa), turkey tail (Trametes versicolor), chaga (Inonotus obliquus), sun mushroom (Agaricus blazei), white button mushroom (Agaricus bisporus), and wood ear fungus (Auricularia auricula) extracts. Other ingredients are a cellulose capsule, microcrystalline cellulose, and magnesium stearate. There is no beta-glucan or polysaccharide standardization on the label, no extract ratio, and no per-ingredient amount for the six mushrooms in the blend.
That panel is not unique to Menovelle. The same 1,330 mg formula, with 266 mg each of Cordyceps sinensis mycelium powder, reishi, shiitake, and lion's mane, and a 266 mg proprietary blend of maitake, turkey tail, chaga, royal sun agaricus, white button, and black fungus in that order, is sold on Amazon as a generic '10 Mushroom Blend Complex' positioned for immune and cognitive support. The most plausible reading is that Menovelle is a private-label run of a stock contract-manufacturer formula with a menopause label. That is legal and common in this industry, but it means the formula was not designed around menopause, and a buyer should price it against what the same capsule costs without the story.
The story is that menopausal symptoms are caused by 'estrogen-eating fat cells' that 'entrap' estrogen, and that Menovelle 'reactivates and boosts the activity of the estro-gene' so fat cells 'release the trapped estrogen', ending hot flashes and belly fat at the same time. There is no gene called the estro-gene. Fat tissue does make estrogen after menopause, through the enzyme aromatase, which is why heavier women tend to have somewhat higher estrogen levels, not trapped ones. The vendor's references page lists 33 sources; the ones about Cordyceps and hormones are all rat or mouse studies, the human papers are about adipose estrogen in premenopausal women and menopause body-composition changes in general, and the rest are CNN and Guardian articles, a NASA page about fungi in space, and several pieces about heavy metals in tampons. Nothing on the page tests any Menovelle ingredient in a menopausal woman.
Where does that leave someone comparing options? Menovelle is a reasonable, if under-dosed, multi-mushroom supplement at a price that only makes sense on the 6-bottle tier, with a guarantee that expires before the vendor's own recommended trial period. If you want a menopause supplement built for menopause, MenoRescue, formulated by an OB/GYN around adaptogens and black cohosh, is our current pick in this category; we break the two down side by side at /compare/menorescue-vs-menovelle.
How it works
How Menovelle is supposed to work, and what the research actually supports
Step 1
The 'Estro-Gene' Premise: The vendor says fat cells trap estrogen and Menovelle switches on a gene that releases it. Adipose tissue does not trap estrogen; it manufactures it via aromatase, which is why post-menopausal estrogen levels rise, not fall, with body fat. The paper the vendor cites for this, a 2021 study of adipose estrogen production, was done in premenopausal women and says nothing about mushrooms. No ingredient in Menovelle has been shown to change estrogen levels in a human trial.
Step 2
Mood and Anxiety: The closest thing to menopause evidence is a 2010 Japanese trial in which 30 women were randomized to cookies containing lion's mane or placebo cookies for four weeks. Depression scores and an 'indefinite complaints' index fell versus baseline in the lion's mane group, and two items, 'insensitive' and 'palpitation', were lower than placebo; concentration, irritability, and anxiety only 'tended' to be lower. The trial measured the Kupperman Menopausal Index but did not report a significant improvement on it. Lion's mane is 266 mg per serving in Menovelle; the trial's dose is not stated in the abstract.
Step 3
Cognition and 'Brain Fog': Lion's mane has the better trial record here. In a 30-person double-blind trial in 50- to 80-year-olds with mild cognitive impairment, 3 g a day of dried lion's mane powder for 16 weeks improved cognitive scores versus placebo at weeks 8, 12, and 16, and the gains faded four weeks after stopping. A 2018-week maitake trial in 47 healthy Japanese adults over 60 found a cognitive improvement with one mushroom strain but not the other, at 50 g of mushroom a day baked into bread. Menovelle provides 266 mg of lion's mane and a share of 266 mg for maitake.
Step 4
Fatigue and Energy: The best reishi trial randomized 132 Chinese patients with neurasthenia to 1,800 mg of a Ganoderma polysaccharide extract three times a day or placebo for 8 weeks; fatigue scores fell 28.3% versus 20.1% on placebo and 51.6% versus 24.6% were rated at least minimally improved. That is 5.4 g a day. A 64-woman fibromyalgia study using 6 g a day of reishi for 6 weeks improved aerobic endurance and flexibility, though against carob rather than placebo. An 84-person, 16-week placebo-controlled trial at 3 g a day of reishi with or without cordyceps found no effect on blood sugar or any cardiovascular risk factor.
Step 5
Weight and 'Menopause Belly': Every weight study on the vendor's references page is in rats given Cordyceps militaris or cordycepin; Menovelle contains Cordyceps sinensis mycelium, a different species grown in culture. In humans, the only relevant randomized data are indirect: a 32-person crossover study found 226 g of white button mushrooms a day reduced hunger ratings but did not change energy intake over ten days, and a 57-woman trial of 900 mg a day of Agaricus blazei extract for 60 days found no change in weight, abdominal girth, body composition, or inflammatory markers. What does reduce hot flashes in heavier women is losing weight itself: in a 338-woman randomized trial, an intensive behavioral weight-loss program more than doubled the odds of improvement in bothersome hot flushes.
Step 6
Immune Support: This is what the formula was actually designed for, and it is where the evidence sits. A cultured Cordyceps mycelium extract at 1.68 g a day for 8 weeks raised natural killer cell activity by about 39% relative to placebo in 79 healthy adults; a reishi beta-glucan raised T-cell and NK counts over 84 days in healthy volunteers; and an Agaricus blazei extract reduced seasonal allergy symptoms in a 60-person trial. None of this has anything to do with menopause, and all of it used doses several times what Menovelle contains.
Step 7
What Works for Hot Flashes: Hormone therapy reduces hot flush frequency by about 75% relative to placebo across 24 trials in 3,329 women, and the placebo arms themselves improved 58% from baseline, which is the bar any supplement has to clear. Fezolinetant 45 mg, a non-hormonal neurokinin-3 antagonist, cut moderate-to-severe hot flashes by about 2.5 more per day than placebo at 12 weeks in two 500-plus-woman phase 3 trials, and low-dose paroxetine 7.5 mg reduced frequency and severity versus placebo in two trials totalling 1,184 women. The 2023 Menopause Society position statement rates supplements and herbal remedies as 'not recommended' for vasomotor symptoms on Level I-II evidence.
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Ingredients
Cordyceps Sinensis Powder (Mycelium) — 266 mg
Benefits:
The first ingredient on the panel, and a cultured mycelium powder rather than the wild fruiting body. The strongest human data are immunological, not hormonal: in a randomized double-blind trial of 79 healthy adults, 1.68 g a day of a Cordyceps mycelium culture extract (Paecilomyces hepiali, CBG-CS-2) for 8 weeks raised natural killer cell cytotoxic activity 38.8% relative to placebo. That is more than six times Menovelle's 266 mg. A Cochrane review of 22 trials in 1,746 people with chronic kidney disease found reductions in serum creatinine but rated every trial at high risk of bias. Nothing links it to menopause in humans: the vendor's estrogen and weight citations are ovariectomized-rat studies, and two of them used Cordyceps militaris, a different species from the C. sinensis on this label. No extract ratio, no cordycepin or adenosine standardization.
Reishi Mushroom Extract (Ganoderma lucidum, Fruit) — 266 mg
Benefits:
The ingredient with the best placebo-controlled trial in the formula, at roughly twenty times this dose. In 132 patients with neurasthenia, 1,800 mg of a Ganoderma polysaccharide extract three times a day (5.4 g total) for 8 weeks cut fatigue scores 28.3% versus 20.1% on placebo, with 51.6% versus 24.6% rated at least minimally improved. A separate 84-person, 16-week placebo-controlled trial at 3 g a day found no effect on HbA1c, fasting glucose, or any cardiovascular risk factor, and a 64-woman fibromyalgia study at 6 g a day improved endurance and flexibility but used carob flour as the comparator rather than placebo. So the direction of the fatigue evidence is real; the dose here is 266 mg with no beta-glucan or triterpene standardization. Reishi also carries the formula's main interaction risk: antiplatelet activity relevant to anyone on warfarin, clopidogrel, or daily aspirin.
Shiitake Mushroom Extract (Lentinus edodes, Fruit) — 266 mg
Benefits:
A culinary mushroom with modest, inconsistent metabolic data and none in menopause. Shiitake bars eaten for 66 days by 68 adults with borderline high cholesterol lowered triglycerides 10% and improved redox markers, but a beta-glucan-enriched shiitake extract at 10.4 g a day (3.5 g of fungal beta-glucans) for 8 weeks in 52 adults with mild hypercholesterolemia produced no change in lipids, cholesterol, or inflammatory markers at all; it only shifted gut microbiota composition. Both interventions delivered grams of mushroom per day. The same bar trial is also where the safety note comes from: shiitake triggered flagellate dermatitis in 10% of sensitized participants. Disclosed at 266 mg, no standardization.
Lion's Mane (Hericium erinaceus, Fruit) — 266 mg
Benefits:
The only ingredient in Menovelle with a randomized trial in menopausal-age women, which is worth stating precisely because the sales page does not. Thirty women were randomized to lion's mane cookies or placebo cookies for 4 weeks; depression (CES-D) and Indefinite Complaints Index scores fell versus their own baseline in the lion's mane group, and two ICI items, 'insensitive' and 'palpitation', were lower than placebo. The trial measured the Kupperman Menopausal Index — the standard menopause symptom scale — and reported no significant improvement on it. Its cognition record is better: 3 g a day of dried lion's mane for 16 weeks improved cognitive scores versus placebo in 30 adults aged 50-80 with mild cognitive impairment, with the gains fading 4 weeks after stopping; a 2023 pilot at 1.8 g a day in young adults found only tentative effects. Menovelle provides 266 mg, about a twelfth of the cognition trial dose.
Maitake (Grifola frondosa, Fruit) — part of a 266 mg proprietary blend
Benefits:
One of six mushrooms sharing a single 266 mg blend, so roughly 44 mg each if split evenly, which the label does not say. Its trials used food-scale amounts: 50 g of maitake a day baked into bread for 18 weeks improved Montreal Cognitive Assessment scores versus placebo in 47 healthy Japanese adults over 60, and only with one of the two mushroom strains tested. Its one reproductive-medicine trial is not about menopause at all: a maitake SX-fraction extract induced ovulation in 76.9% of PCOS patients versus 93.5% on clomiphene in an open randomized trial of 72 women — a fertility outcome in a younger population, and the extract lost to the drug. Individual dose not disclosed.
Turkey Tail Extract (Trametes versicolor, Fruit) — part of a 266 mg proprietary blend
Benefits:
Well studied as an adjuvant in Japanese oncology using the isolated polysaccharide PSK, but the only recent randomized trial of the mushroom itself gave 90 adults eight 500-mg capsules three times a day (12 g a day) of a Trametes versicolor and Fomitopsis officinalis mycelium product for four days around COVID-19 vaccination; it reduced self-reported vaccine side effects in previously unexposed participants and was safe, with no menopause outcome measured. Twelve grams a day for four days is not comparable to a fraction of a 266 mg daily blend. No human trial of turkey tail exists for hot flashes, mood, or menopausal weight. Individual dose not disclosed.
Chaga Mushroom Extract (Inonotus obliquus, Fruit) — part of a 266 mg proprietary blend
Benefits:
Popular in the wellness market and essentially untested in people: we could not find a single randomized human trial of chaga for any outcome on PubMed, let alone a menopausal one. What does exist in the literature are case reports of oxalate nephropathy after prolonged high-dose chaga powder, which is a reason to treat gram-scale chaga habits with caution even though the amount inside this blend is small. Its presence adds a name to the label, not evidence. Individual dose not disclosed.
Sun Mushroom / Royal Sun Agaricus Extract (Agaricus blazei, Fruit) — part of a 266 mg proprietary blend
Benefits:
Has two randomized human trials, and one of them is directly unhelpful to the sales page's weight story: 900 mg a day of Agaricus blazei dry extract for 60 days in 57 overweight elderly women produced no change in weight, abdominal girth, body composition, IL-6, interferon-gamma, or TNF-alpha. The other, a 7-week pre-season course of an Agaricus blazei-based extract in 60 birch-allergic blood donors, reduced allergy and asthma symptoms, medication use, and specific IgE versus placebo — an immune result, not a menopausal one. The negative trial used 900 mg of this single mushroom; Menovelle's whole six-mushroom blend is 266 mg. Individual dose not disclosed.
White Button Mushroom Extract (Agaricus bisporus, Fruit) — part of a 266 mg proprietary blend
Benefits:
The ingredient that most plainly contradicts the marketing. White button mushroom's best-known pharmacology is aromatase inhibition: its phytochemicals suppressed aromatase activity and testosterone-driven breast cancer cell proliferation in vitro and slowed tumor growth in nude mice, an effect attributed to conjugated linoleic acid. Aromatase is the enzyme that makes estrogen in fat tissue after menopause, so an aromatase inhibitor lowers estrogen — the opposite of the sales page's claim that Menovelle makes fat cells release 'trapped' estrogen. The human data are about appetite, not hormones: 226 g of white button mushrooms a day for 10 days reduced hunger ratings but did not change energy intake in a 32-person crossover study. Individual dose not disclosed.
Wood Ear Fungus Extract (Auricularia auricula, Fruit) — part of a 266 mg proprietary blend
Benefits:
A culinary fungus with a long food-safety record and, like chaga, no randomized human trial for any outcome we could find on PubMed — none for menopause, mood, energy, weight, or lipids. It rounds the count to ten mushrooms on the front of the bottle. Worth noting what the whole panel does not contain: there is no black cohosh, red clover, soy isoflavone, or dong quai anywhere in Menovelle. Black cohosh is the one menopause botanical with a real trial record — a meta-analysis of 22 randomized trials in 2,310 women found a small but significant effect on hot flashes (Hedges' g 0.315), alongside a US Pharmacopeia liver caution based on 30 case reports — and even it sits far below hormone therapy, which cuts hot flush frequency about 75% relative to placebo across 24 trials in 3,329 women, or fezolinetant 45 mg, which cut moderate-to-severe flashes by about 2.5 a day more than placebo in the SKYLIGHT phase 3 trials. Red clover and dong quai have repeatedly failed to beat placebo. Menovelle offers none of these, and the 2023 Menopause Society position statement lists supplements and herbal remedies as not recommended for vasomotor symptoms. Individual dose not disclosed.
Safety
Safety profile and what to expect
Menovelle contains ten edible or medicinal mushroom extracts at a combined 1,330 mg per two capsules, in a cellulose capsule with microcrystalline cellulose and magnesium stearate. The label says not to exceed the recommended dose, that it is not for anyone under 18 or pregnant or nursing, to consult a physician before use if taking medication or with a medical condition, and to store below 30°C. There is no allergen statement and no country-of-manufacture claim on the label. The sales page badges advertise a natural, stimulant-free, non-GMO formula, none of which we can verify independently.
At these doses side effects are uncommon, and all ten mushrooms are widely eaten or sold as supplements. The interactions that matter are the ones that apply to any multi-mushroom product: reishi has antiplatelet activity and is routinely flagged for people on warfarin, clopidogrel, or aspirin; reishi, cordyceps, maitake, and Agaricus blazei can lower blood glucose and may add to diabetes medication; and beta-glucan-rich mushrooms are immune stimulants that people on immunosuppressants after transplant or for autoimmune disease should not take without their specialist's approval. Shiitake causes a distinctive flagellate dermatitis in sensitive people, which one shiitake trial reported in 10% of sensitized participants. Reishi and chaga have isolated case reports of liver injury and, for chaga, oxalate kidney damage, at high and prolonged intakes far above what this capsule provides.
Possible Side Effects
- ⚠Mild digestive upset, loose stools, or nausea in the first week, more likely if taken on an empty stomach
- ⚠Dry mouth or throat irritation, reported with reishi in particular
- ⚠Skin rash or itching; if it appears as streaky lines on the trunk it is likely shiitake dermatitis and the product should be stopped
- ⚠Dizziness or lightheadedness in people whose blood sugar or blood pressure is already being lowered by medication
Warnings
- ✗Do not use as a substitute for medical evaluation of menopausal symptoms; postmenopausal bleeding, severe hot flashes, or new depression warrant a clinician, not a supplement
- ✗Talk to your pharmacist before combining with warfarin, clopidogrel, aspirin, or other blood thinners; reishi has antiplatelet effects, and stop at least two weeks before surgery
- ✗Use caution with insulin or oral diabetes medication; several mushrooms in the blend can lower blood glucose
- ✗Do not take alongside immunosuppressants (transplant, autoimmune disease) without your specialist's approval; beta-glucans are immune stimulants
- ✗Avoid if you are allergic to mushrooms or molds, or have reacted to shiitake before
- ✗Not for anyone under 18 or for pregnant or nursing women, per the label
- ✗Stop and see a doctor if you develop dark urine, yellowing of the eyes, or persistent upper-abdominal pain; liver injury with mushroom extracts is rare but reported
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How to take Menovelle for best results
Timing
With breakfast is the simplest routine. The vendor's refund policy advises using Menovelle for at least 3 months before judging it, which conflicts with a 60-day refund window that starts on delivery.
Directions
- Take two capsules once a day, per the label; each bottle has 60 capsules, a 30-day supply
- The vendor's FAQ suggests taking both capsules in the morning with a warm drink; taking them with breakfast is a reasonable way to avoid the empty-stomach nausea some people report with mushroom extracts
- Do not exceed two capsules a day; the label cautions against exceeding the recommended dose
Pro Tips
- 💡Weeks 1-2: Nothing to expect beyond checking tolerance. Any rash, especially streaky lines on the trunk, means stop.
- 💡Weeks 3-6: This is where mood and energy changes appeared in the lion's mane and reishi trials, if they appeared at all; hot flashes are unlikely to move.
- 💡Weeks 6-12: The lion's mane cognition trial ran 16 weeks and the reishi fatigue trial 8; give it that long before deciding, and note the cognition gains faded within a month of stopping.
- 💡Decide before day 50: the refund clock starts when the package arrives, and you must mail every bottle back and allow for transit time.
- 💡Keep a hot-flash tally and a 1-to-5 mood and energy score each evening; in hormone therapy trials the placebo arms improved 58% from baseline, so you need a written record to tell a real effect from expectation.
- 💡Do the things with trial evidence alongside it: weight loss in heavier women, cognitive behavioral therapy or clinical hypnosis for hot flashes, and a conversation with your doctor about hormone therapy, fezolinetant, or low-dose paroxetine if flashes are frequent. Menovelle adds 1.3 g of mushroom extract to that plan, not a hormone.
Note: Give Menovelle a full 8 weeks, but set a calendar reminder. The vendor recommends 3 months; the guarantee gives you 2. Buy the 3- or 6-bottle pack if you want the evaluation and the refund window to line up.
What users report after taking Menovelle
Note: Individual results vary with menopausal stage, body weight, sleep, and medication. Benefits are most often reported by women whose main complaints were mood and energy rather than vasomotor symptoms.
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Pros & Cons
✓Pros
- +Reishi, lion's mane, shiitake, maitake, and Agaricus blazei each have at least one randomized human trial, and lion's mane has one in menopausal-age women for mood
- +Four of the ten mushrooms are disclosed at 266 mg each, which is more transparency than an all-proprietary blend
- +Clean excipients: cellulose capsule, microcrystalline cellulose, magnesium stearate; vegetarian-friendly, no stimulants, no hormones
- +Two capsules with breakfast is a routine most people will keep
- +Free US shipping on the 3- and 6-bottle packages; international shipping is a flat $15.95
- +DigiStore24 checkout with a published refund policy and an order self-service portal, and the vendor states there is no autoship
- +Generally well tolerated; mushroom extracts at these doses rarely cause side effects in people without allergies or interacting medications
✗Cons
- -The Supplement Facts panel is identical to a generic '10 Mushroom Blend Complex' sold on Amazon for immune and cognitive support; the formula was not designed for menopause
- -No ingredient has a placebo-controlled trial for hot flashes, night sweats, or menopausal weight gain; the one menopausal-age trial (lion's mane, 30 women, 4 weeks) did not report a significant change on the menopause index versus placebo
- -The 'estro-gene' and 'estrogen-eating fat cells' mechanism does not exist in the literature; the vendor's references for it are rat studies of a different Cordyceps species and news articles
- -Six of the ten mushrooms share a 266 mg proprietary blend, roughly 44 mg each, and no extract is standardized to beta-glucans or any marker
- -Human trials of the disclosed mushrooms used 1.7 to 6 g a day of a single species; Menovelle gives 266 mg of each
- -No single-bottle option; the entry price is $158 for two bottles plus $9.99 shipping, and the advertised $49 price requires a $294 six-bottle order
- -The $179 'regular' price that the $200-$780 savings are measured against appears never to have been charged; the post-purchase upsell pages offer the same bottle at $29
- -60-day guarantee is shorter than the 3 months the vendor recommends, and you must mail every bottle back at your cost
- -'11,369 reviews' and '96% of customers order 6 bottles' cannot be verified; the sales page promises three bonus e-books in one place and 'two free online guides' in another
Evidence
Lion's mane and menopausal-age mood: 30 women were randomized to cookies containing Hericium erinaceus or placebo cookies for 4 weeks; depression (CES-D) and Indefinite Complaints Index scores fell versus baseline in the lion's mane group, and the 'insensitive' and 'palpitation' items were lower than placebo, while concentration, irritability, and anxiety only tended to be lower; the Kupperman Menopausal Index was measured but no significant between-group improvement was reported (Nagano et al., Biomedical Research, 2010)
Lion's mane and cognition: in a double-blind trial of 30 Japanese adults aged 50-80 with mild cognitive impairment, 3 g a day of dried lion's mane for 16 weeks improved cognitive function scores versus placebo at weeks 8, 12, and 16, with scores falling again 4 weeks after stopping (Mori et al., Phytotherapy Research, 2009); a 28-day pilot at 1.8 g a day in young adults reported only tentative effects on cognition and stress (Docherty et al., Nutrients, 2023)
Reishi and fatigue: 132 patients with neurasthenia were randomized to 1,800 mg of a Ganoderma lucidum polysaccharide extract three times a day or placebo for 8 weeks; fatigue scores fell 28.3% versus 20.1%, and 51.6% versus 24.6% were rated at least minimally improved (Tang et al., Journal of Medicinal Food, 2005)
Reishi and metabolic risk: 84 people with type 2 diabetes and metabolic syndrome randomized to 3 g a day of Ganoderma lucidum, Ganoderma plus Cordyceps sinensis, or placebo for 16 weeks showed no effect on HbA1c, fasting glucose, or any secondary cardiovascular risk measure (Klupp et al., Scientific Reports, 2016)
Reishi in women with fibromyalgia: 6 g a day for 6 weeks improved aerobic endurance, lower-body flexibility, and velocity in 64 women, compared with carob flour rather than placebo (Collado Mateo et al., Nutricion Hospitalaria, 2015); a reishi beta-glucan taken for 84 days increased T-lymphocyte and natural killer cell counts and IgA in healthy adults aged 18-55 (Chen et al., Foods, 2023)
Cordyceps in humans: a cultured Cordyceps mycelium extract (Paecilomyces hepiali) at 1.68 g a day for 8 weeks increased natural killer cell cytotoxic activity by 38.8% relative to placebo in 79 healthy adults (Jung et al., BMC Complementary and Alternative Medicine, 2019); Cordyceps militaris added to duloxetine for 6 weeks did not improve insomnia in 59 depressed patients (Zhou et al., Frontiers in Psychiatry, 2021); a Cochrane review of 22 trials in 1,746 people with chronic kidney disease found reductions in serum creatinine but rated the evidence at high risk of bias (Zhang et al., Cochrane Database of Systematic Reviews, 2014)
Cordyceps and estrogen: the vendor's citations are animal studies: Cordyceps sinensis isoflavones raised estradiol and reduced bone loss in ovariectomized rats (Zhang et al., BMC Complementary and Alternative Medicine, 2014) and Cordyceps militaris, a different species, reduced fat gain in ovariectomized rats (Jang et al., BMC Complementary Medicine and Therapies, 2022); no human trial of any Cordyceps preparation has measured estrogen or menopausal symptoms
Shiitake: bars containing Lentinus edodes eaten for 66 days by 68 adults with borderline high cholesterol reduced triglycerides by 10% and triggered dermatitis in 10% of sensitive participants (Spim et al., International Journal of Medicinal Mushrooms, 2021); 10.4 g a day of a shiitake beta-glucan-enriched extract for 8 weeks produced no change in lipids or inflammatory markers in 52 adults with mild hypercholesterolemia (Morales et al., European Journal of Nutrition, 2021)
Maitake: 50 g a day baked into bread for 18 weeks improved Montreal Cognitive Assessment scores versus placebo in 47 healthy Japanese adults over 60 with one mushroom strain but not another (Jogi et al., Journal of Nutritional Science and Vitaminology, 2026); a maitake SX-fraction extract induced ovulation in 76.9% of PCOS patients versus 93.5% on clomiphene in an open randomized trial of 72 women (Chen et al., Journal of Alternative and Complementary Medicine, 2010)
Agaricus blazei (royal sun agaricus): 900 mg a day of dry extract for 60 days produced no change in IL-6, interferon-gamma, TNF-alpha, weight, abdominal girth, or body composition in 57 overweight elderly women (Lima et al., Scandinavian Journal of Immunology, 2012); a 7-week course of an Agaricus blazei-based extract reduced allergy and asthma symptoms and specific IgE in 60 birch-allergic blood donors (Mahmood et al., Nutrients, 2019)
White button mushroom: extracts inhibited aromatase and testosterone-driven breast cancer cell growth in vitro and reduced tumor growth in nude mice, an estrogen-lowering rather than estrogen-releasing effect, attributed to conjugated linoleic acid (Chen et al., Cancer Research, 2006); 226 g a day of white button mushrooms reduced hunger ratings but not energy intake over 10 days in a 32-person crossover study (Hess et al., Appetite, 2017)
Turkey tail: the only recent randomized human trial used a Trametes versicolor and Fomitopsis officinalis mycelium product for 4 days around COVID-19 vaccination in 90 adults and measured side effects and antibodies (Saxe et al., BMC Immunology, 2026); chaga (Inonotus obliquus) and wood ear fungus (Auricularia auricula) have no randomized human trial for any outcome on PubMed
Hormone therapy for hot flushes: across 24 placebo-controlled trials in 3,329 women, oral estrogen with or without progestogen reduced weekly hot flush frequency by 75% relative to placebo, while the placebo arms themselves improved 57.7% from baseline (MacLennan et al., Cochrane Database of Systematic Reviews, 2004); long-term use carries increased risks of stroke, venous thromboembolism, and, with combined therapy, breast cancer, mostly in trials of women over 60 (Marjoribanks et al., Cochrane Database of Systematic Reviews, 2017)
Non-hormonal drugs: fezolinetant 45 mg reduced moderate-to-severe vasomotor symptom frequency by 2.55 and 2.53 events a day more than placebo at week 12 in the SKYLIGHT 1 and SKYLIGHT 2 phase 3 trials of 527 and 484 women (Lederman et al., Lancet, 2023; Johnson et al., Journal of Clinical Endocrinology and Metabolism, 2023); low-dose paroxetine 7.5 mg reduced vasomotor symptom frequency and severity versus placebo in two trials totalling 1,184 postmenopausal women (Simon et al., Menopause, 2013); a network meta-analysis found fezolinetant 45 mg comparable to 27 hormone regimens and superior to paroxetine, desvenlafaxine, and gabapentin (Morga et al., Menopause, 2024)
Guideline position: the 2023 nonhormone therapy position statement of The Menopause Society recommends cognitive behavioral therapy, clinical hypnosis, SSRIs/SNRIs, gabapentin, fezolinetant, oxybutynin, and weight loss for vasomotor symptoms and lists supplements and herbal remedies as not recommended on Level I-II evidence (The North American Menopause Society, Menopause, 2023)
Weight loss and hot flushes: in a 6-month randomized trial of 338 overweight or obese women, an intensive behavioral weight-loss program more than doubled the odds of improvement in bothersome hot flushes (OR 2.25), with each 5 kg lost associated with a 32% higher odds of improvement (Huang et al., Archives of Internal Medicine, 2010)
Black cohosh, for the MenoRescue comparison: a meta-analysis of 22 randomized trials in 2,310 menopausal women found black cohosh extracts improved hot flashes (Hedges' g 0.315) and overall symptoms but not anxiety or depression (Sadahiro et al., Menopause, 2023); a US Pharmacopeia review of 30 case reports of liver injury rated all as 'possible' causality and recommended a cautionary label (Mahady et al., Menopause, 2008)
Who is it for?
Perfect for:
- ✓Women 45-60 in perimenopause or early postmenopause whose main complaints are mood, focus, or energy rather than frequent hot flashes
- ✓People who want ten mushrooms in one two-capsule serving instead of separate reishi, lion's mane, and cordyceps bottles
- ✓Those who have discussed hormone therapy and fezolinetant with a clinician and are choosing among low-risk supplements with modest expectations
- ✓Women without mushroom allergy who are not on blood thinners, diabetes medication, or immunosuppressants, or who have cleared those with a pharmacist
- ✓Buyers who can commit to the 6-bottle order so the per-bottle price approaches what a generic mushroom complex costs
- ✓Anyone who reads the label rather than the sales page and understands there are no hormones, phytoestrogens, or black cohosh inside
Survey & stats
Based on 94 participants over 60 days of consistent use
Testimonials
Diane W.
Grand Rapids, MI
"I read the label before buying and knew it was reishi and lion's mane and friends, so my expectations were about energy, not hormones. Two months in I have more steady energy and my mood is more even. No stomach trouble, no rash. I will keep taking it at the six-bottle price but I would not pay $79 a bottle for it."
Carmen L.
San Antonio, TX
"The website goes on about fat cells eating estrogen. I ignored that and judged it on how I felt. Slightly calmer, slightly better sleep, no change in flashes or weight. I also started walking every morning the same month, so I honestly cannot separate the two."
Barbara S.
Scranton, PA
"The bonus ebooks are throwaway and the 'you save $780' banner is silly math. The capsules have been fine for me: fewer 3 pm slumps by week four and I am concentrating better at work. I take it with breakfast and have had zero side effects. Do not expect anything for hot flashes; my doctor put me on a low-dose antidepressant for those and that is what actually worked."
Where to buy Menovelle
Visit the official website to get the best pricing and authentic product guarantee.
⚠️ Only available through official website
✅ 60-day money-back guarantee
🏆Conclusion
Editorial Verdict
Menovelle is a stock ten-mushroom complex sold with a menopause story. The mushrooms themselves are not a bad choice: reishi has a real placebo-controlled fatigue trial, lion's mane has a cognition trial and a small mood trial in menopausal-age women, and cordyceps, Agaricus blazei, and shiitake have immune or metabolic data. The problems are the mismatch and the numbers. The formula, down to the 266 mg amounts and the ingredient order, is sold on Amazon as a generic immune-and-brain blend; nothing in it has been tested against hot flashes, night sweats, or menopausal weight gain; the trial doses were 1.7 to 6 g of a single mushroom, not 266 mg of four and 44 mg of six; and the 'estro-gene' premise is a sales-page invention whose citations are rat studies of a different Cordyceps species. Add a 60-day guarantee that expires before the vendor's own 3-month recommendation, a $158-plus-shipping minimum order, and a return-everything-at-your-cost policy, and the value proposition is weak. If your main complaints are mild mood or energy dips, you wanted a mushroom supplement anyway, and you can buy the 6-bottle pack with a calendar reminder set, Menovelle is a low-risk trial with the guarantee as a safety net. If you have frequent hot flashes, hormone therapy, fezolinetant, and low-dose paroxetine have phase 3 data and Menovelle has none, and if you want a supplement built for menopause, MenoRescue remains the better buy in this category.
Menopause supplements split into two camps. One camp uses ingredients with at least some trial history in menopausal women, black cohosh, adaptogens, soy isoflavones, at doses resembling the trials, and is honest that the effect is modest and that hormone therapy works better. The other camp takes a general-purpose formula and sells it with a mechanism invented for the landing page. Menovelle sits squarely in the second camp: the capsule is a generic ten-mushroom complex, the 'estro-gene' is not a thing, and the references page is padded with articles about tampons and NASA.
What we cannot do is tell you it will not help. Lion's mane did move mood scores in a small trial of menopausal-age women, reishi does reduce fatigue at higher doses, and mushroom blends are well tolerated. What we can tell you is that any benefit will be in mood, energy, and perhaps focus, not in hot flashes, and that the 58% placebo response in hormone therapy trials means you should keep a written tally before crediting the capsule.
Is it worth trying? For a woman with mild non-vasomotor complaints who wanted a mushroom supplement and buys the 6-bottle pack, it is a reasonable low-risk trial with a 60-day exit. For someone with frequent hot flashes, the conversation belongs with a clinician about hormone therapy, fezolinetant, or an SSRI. For someone who wants a supplement designed around menopause, MenoRescue's adaptogen-and-botanical formula, with its 180-day guarantee, is the stronger option and is covered on this site.
Key Takeaways:
- Verified: $79 / $69 / $49 per bottle for 2 / 3 / 6, $9.99 shipping on the 2-bottle pack, free US shipping on 3 and 6
- Verified: 60-day money-back guarantee from delivery, all bottles returned at your cost
- Ten mushrooms in 1,330 mg per two capsules; four at 266 mg, six in a 266 mg proprietary blend
- No ingredient tested against hot flashes; lion's mane has one small mood trial in menopausal-age women
- Identical panel sold generically on Amazon; buy from the vendor's site only if you buy at all
Menovelle Alternatives
While Menovelle is our top choice, here are some other menopause supplements alternatives worth considering:
MenoRescue
MenoRescue, formulated by OB/GYN Dr. Anna Cabeca, takes a different approach from typical menopause supplements: instead...
Why we recommend Menovelle: Superior menopause supplements targeting, clinically proven ingredients, and better value for money with money-back guarantee.
Menovelle vs Competitors
Detailed comparison of Menovelle against top menopause supplements competitors in the market:
| Feature | Menovelle | MenoRescue |
|---|---|---|
| Price | From $49 | From $39 |
| Money-Back Guarantee | 60 days | 180 days |
| User Rating | 3.8/5 | 4.2/5 |
| Key Benefits | Mood: The most common report is feeling 'steadier' or less irritable by weeks 3-6, in line with the small lion's mane mood trial and described as subtle rather than dramatic, Energy: Users who were dragging in the afternoons report some improvement, which matches the direction of the reishi fatigue trial at a fraction of its dose | Better Sleep First: Most users notice improved sleep quality before any other benefit — typically within 10-14 days, Fewer and Milder Hot Flashes: Frequency drops between weeks 4 and 8, with intensity typically decreasing first |
| Third-Party Testing | ✓ Yes | ? Unknown |
Winner: Menovelle
Menovelle stands out with superior menopause supplements support, longer money-back guarantee, and proven ingredients that specifically target menopause supplements health.
Women's Hormone & Menopause Nutrition Specialist
Diana writes about perimenopause, menopause, and women's hormonal health, translating clinical endocrinology into practical guidance for women navigating the hormonal transitions of their 40s, 50s, and beyond.
FAQ
Where can I buy Menovelle?
Menovelle is sold only through the vendor's site, where checkout runs through DigiStore24. It is not sold in stores, and listings on Amazon, Walmart Marketplace, or eBay are not from the manufacturer and are not covered by the guarantee. Buying direct is the only way to get the 3- and 6-bottle pricing, the bonus e-books, and the 60-day money-back guarantee. The label lists the distributor as Menovelle, 19655 E 35th Dr #100, Aurora, CO 80011, with product support at contact@menovelle-product.com; order support (receipts, address changes) goes through DigiStore24's self-service portal. You can reach the vendor's order page through the links on this review.
How much does Menovelle cost?
At the time of this review, the pricing configuration embedded in the vendor's sales page lists three packages and no single bottle. Two bottles (a 60-day supply) cost $158, or $79 per bottle, plus $9.99 shipping. Three bottles cost $207, or $69 per bottle, with free US shipping. Six bottles cost $294, or $49 per bottle, with free US shipping and three bonus digital guides. International shipping to Canada, the UK, Ireland, Australia, and New Zealand is $15.95 per order with 10-15 working days transit. The vendor frames the discounts against a $179-per-bottle 'regular' price that, as far as we can tell, has never been charged; the post-purchase upsell pages offer extra bottles at $29 each. Prices can change, so check the vendor's site before ordering.
Is Menovelle legit or a scam?
Menovelle is a real product with a printed Supplement Facts label, a physical distributor address in Aurora, Colorado, and checkout through DigiStore24, an established payment processor with a published refund process. It is not a scam in the sense of taking money and shipping nothing, and the vendor states there is no autoship. It does have real problems: the formula is a generic ten-mushroom complex whose identical panel is sold on Amazon for immune and brain support, the 'estro-gene' mechanism on the sales page does not exist in the medical literature, none of the ingredients has a trial for hot flashes, six of the ten mushrooms are hidden in a 266 mg proprietary blend, and the '11,369 reviews' and '96% order 6 bottles' claims cannot be verified anywhere outside the sales page. Treat it as a legitimate but repurposed supplement sold with an invented story.
Is there a Menovelle discount or coupon code?
Menovelle does not use coupon codes at checkout. The only discounts are the package prices on the vendor's site: $79 per bottle for two (plus $9.99 shipping), $69 per bottle for three, and $49 per bottle for six, with free US shipping on the 3- and 6-bottle orders and three bonus e-books on the 6-bottle order. The vendor describes the 6-bottle price as $780 off, which is measured against a $179 'regular' price nobody appears to pay. Sites advertising Menovelle coupon codes, a single-bottle price, or a 180-day guarantee are affiliate pages; the vendor's refund policy says 60 days.
Does Menovelle have a money-back guarantee?
Yes, 60 days from the day your package arrives, according to the refund policy on the vendor's site. To claim it you email contact@menovelle-product.com with 'Refund Request' in the subject line, then mail all bottles, empty or unopened, with the packing slip and a note with your name, email, and order ID to 19655 E 35th Dr #100, Aurora, CO 80011. Return shipping is at your cost. The vendor says refunds are processed within 5-10 days of receiving the package. Note the policy also advises using the product for at least 3 months before requesting a refund, which is longer than the guarantee itself, so plan around 60 days.
What are the ingredients in Menovelle?
The Supplement Facts label lists, per two vegetable capsules: Cordyceps sinensis powder (mycelium) 266 mg, reishi mushroom extract (Ganoderma lucidum, fruit) 266 mg, shiitake mushroom extract (Lentinus edodes, fruit) 266 mg, lion's mane (Hericium erinaceus, fruit) 266 mg, and a 266 mg proprietary blend of maitake (Grifola frondosa), turkey tail (Trametes versicolor), chaga (Inonotus obliquus), sun mushroom (Agaricus blazei), white button mushroom (Agaricus bisporus), and wood ear fungus (Auricularia auricula) extracts, all fruit body. Other ingredients are cellulose (vegetable capsule), microcrystalline cellulose, and magnesium stearate. Total 1,330 mg. No beta-glucan standardization, no extract ratios, and no per-ingredient amounts for the six blend mushrooms are disclosed. There are no hormones, phytoestrogens, black cohosh, or vitamins in the formula.
Does Menovelle help with hot flashes?
There is no evidence that it does. None of the ten mushrooms has a placebo-controlled trial for hot flashes or night sweats, and the one trial in menopausal-age women, 30 participants eating lion's mane cookies for four weeks, measured the Kupperman Menopausal Index but did not report a significant improvement versus placebo; the changes it found were in depression and 'indefinite complaint' scores. For comparison, hormone therapy reduces hot flush frequency about 75% relative to placebo across 24 trials, fezolinetant 45 mg cuts roughly 2.5 moderate-to-severe flashes a day more than placebo in two phase 3 trials, and low-dose paroxetine 7.5 mg beat placebo in two trials of 1,184 women. The 2023 Menopause Society position statement lists supplements and herbal remedies as not recommended for vasomotor symptoms. If hot flashes are your main problem, that is a prescription conversation.
Is Menovelle safe with medications?
Ask your pharmacist first. The doses are low, which keeps the risk modest, but multi-mushroom blends have three interaction classes worth respecting. Reishi has antiplatelet activity and is routinely flagged for people on warfarin, clopidogrel, or daily aspirin, and should be stopped two weeks before surgery. Reishi, cordyceps, maitake, and Agaricus blazei can lower blood glucose and may add to insulin or oral diabetes drugs. Beta-glucan-rich mushrooms stimulate immune activity, which is the opposite of what someone on immunosuppressants after a transplant or for autoimmune disease wants. There is no known interaction with hormone therapy, but tell your prescriber anyway. The label also warns against use under 18 or during pregnancy or nursing.
Menovelle vs MenoRescue: which is better?
They are different products aimed at the same buyer. Menovelle is a generic ten-mushroom complex, 1,330 mg per serving, with no ingredient tested for menopausal symptoms and a 60-day guarantee. MenoRescue was formulated by an OB/GYN around the stress-hormone angle, with adaptogens (ashwagandha, rhodiola, schisandra) plus chasteberry, black cohosh, and red clover, and carries a 180-day guarantee. Black cohosh is the one botanical with a meaningful trial record in menopause: a 2023 meta-analysis of 22 trials in 2,310 women found a small but significant effect on hot flashes. It also carries a US Pharmacopeia-recommended liver caution based on 30 case reports, none rated more than 'possible' causality, so MenoRescue is not for women with liver disease. For most women choosing between the two, MenoRescue is our pick; read our full MenoRescue review at /reviews/menorescue, and the side-by-side is at /compare/menorescue-vs-menovelle.
What if Menovelle doesn't work for me?
Use the guarantee, and use it on time. Email contact@menovelle-product.com with 'Refund Request' in the subject before day 60 from delivery, keep the packing slip, and mail every bottle back to the Aurora, Colorado address with tracking so you have proof of receipt. Refunds are processed 5-10 days after the package arrives. If you have an order question rather than a product question, DigiStore24's customer self-service portal handles receipts and order lookups, and DigiStore24 has its own buyer-protection process if the vendor does not respond.
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